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Article

Whole-Genome Sequencing Analysis of Human Metabolome in Multi-Ethnic Populations.

Nature communications - 30 May 2023

Feofanova Elena V, Brown Michael R, Alkis Taryn, Manuel Astrid M, Li Xihao, Tahir Usman A, Li Zilin, Mendez Kevin M, Kelly Rachel S, Qi Qibin, Chen Han, Larson Martin G, Lemaitre Rozenn N, Morrison Alanna C, Grieser Charles, Wong Kari E, Gerszten Robert E, Zhao Zhongming, Lasky-Su Jessica, Yu Bing

Abstract excerpt

Circulating metabolite levels may reflect the state of the human organism in health and disease, however, the genetic architecture of metabolites is not fully understood. We have performed a whole-genome sequencing association analysis of both common and rare variants in up to 11,840 multi-ethnic participants from five studies with up to 1666 circulating metabolites. We have discovered 1985 novel...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37253714
DOI: 10.1038/s41467-023-38800-2
PMCID: PMC10229598

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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