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Deciphering causal proteins in Alzheimer’s disease: A novel Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction

2023-02-24

Abstract excerpt

<h4>Summary</h4> Hidden confounding biases hinder identifying causal protein biomarkers for Alzheimer’s disease in non-randomized studies. While Mendelian randomization (MR) can mitigate these biases using protein quantitative trait loci (pQTLs) as instrumental variables, some pQTLs violate core assumptions, leading to biased conclusions. To address this, we propose MR-SPI, a novel MR method that selects valid pQT...

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Literature Corpus work
1d078bfb-a5f2-5240-b841-0250b2d39c5e
DOI
10.1101/2023.02.20.23286200
Open publication

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Deciphering causal proteins in Alzheimer’s disease: A novel Mendelian randomization method integrated with AlphaFold3 for 3D structure predictionDOI 10.1101/2023.02.20.23286200
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