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Blockade of ZMIZ1‐GATA4 Axis Regulation Restores Youthfulness to Aged Cartilage

5 Mar 2025

Abstract excerpt

Susceptibility to cartilage degeneration increases in an age-dependent manner and older cartilage exhibits increased catabolic factor expression leading to osteoarthritis (OA). While inhibition of cellular senescence can prevent age-related diseases, the understanding of the regulators governing cartilage senescence and the potential for senolytic intervention remains limited. Here, in vitro and in vivo results...

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PMID: 40040621
DOI: 10.1002/advs.202404311

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