Article
Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
2023-03-06
Abstract excerpt
<title>Abstract</title> <p>Osteoarthritis (OA) is an age-related degenerative disease without disease-modifying therapy. The lack of aging-induced osteoarthritis models makes the discovery of therapeutic drugs more challenging. The deficiency of integral membrane zinc metalloprotease ZMPSTE24 could induce Hutchinson-Gilford progeria syndrome (HGPS), a genetic disorder of rapid aging. However, the relationship bet...
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Identifiers and source
- Literature Corpus work
- 82d8612c-f4d7-59c8-94c4-c853475fd14d
- DOI
- 10.21203/rs.3.rs-1779887/v1