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The role of GATA4 in mesenchymal stem cell senescence: A new frontier in regenerative medicine

24 Dec 2024

Abstract excerpt

The Mesenchymal Stem Cell (MSC) is a multipotent progenitor cell with known differentiation potential towards various cell lineage, making it an appealing candidate for regenerative medicine. One major contributing factor to age-related MSC dysfunction is cellular senescence, which is the hallmark of relatively irreversible growth arrest and changes in functional properties. GATA4, a zinc-finger transcription...

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PMID: 39811069
DOI: 10.1016/j.reth.2024.11.017

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