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Article

Identification of FOXO1 as a geroprotector in human synovium through single-nucleus transcriptomic profiling

12 Dec 2023

Abstract excerpt

The synovium, a thin layer of tissue that is adjacent to the joints and secretes synovial fluid, undergoes changes in aging that contribute to intense shoulder pain and other joint diseases. However, the mechanism underlying human synovial aging remains poorly characterized. Here, we generated a comprehensive transcriptomic profile of synovial cells present in the subacromial synovium from young and aged...

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PMID: 38092362
DOI: 10.1093/procel/pwad060

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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