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Cellular senescence in osteoarthritis and anti-aging strategies.

Mechanisms of ageing and development - 1 Oct 2018

Hou Angyang, Chen Peng, Tang He, Meng Haoye, Cheng Xiaoqing, Wang Yu, Zhang Yuming, Peng Jiang

Abstract excerpt

In older adults, the prevalence of osteoarthritis (OA) increases directly with age and is the most common cause of chronic disability. It is necessary to recognize that OA is a degenerative disease that strongly correlates with age, and often promotes elevated levels of cartilage injury. Chondrocytes undergo an age-dependent decline in proliferative and synthetic capacity. It is thought that cellular senescence...

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PMID: 30107185
DOI: 10.1016/j.mad.2018.08.002

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