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Article

Role of the Inflammation-Autophagy-Senescence Integrative Network in Osteoarthritis

25 Jun 2018

Abstract excerpt

Osteoarthritis is the most common musculoskeletal disease causing chronic disability in adults. Studying cartilage aging, chondrocyte senescence, inflammation, and autophagy mechanisms have identified promising targets and pathways with clinical translatability potential. In this review, we highlight the most recent mechanistic and therapeutic preclinical models of aging with particular relevance in the context...

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PMID: 29988615
DOI: 10.3389/fphys.2018.00706

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