Article

Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting SIRT6

2023-11-20

Abstract excerpt

<h4>Background: </h4> Osteoarthritis (OA), the most common type of arthritis, is a highly prevalent age-related joint disease particularly in subjects over 65 years old. The chronic rise of senescent cells closely correlates with age-related diseases including OA, and the senescence-associated secretory phenotype (SASP) is implicated in the pathogenesis of OA cartilage degeneration. Sirtuin 6 (SIRT6) is probable t...

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Literature Corpus work: 5bd3eec3-b49c-527c-b634-f42bd6d580f6
DOI: 10.21203/rs.3.rs-3601398/v1

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