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Anatomical and functional phenotyping of mice models of Alzheimer's disease by MR microscopy.

Annals of the New York Academy of Sciences - 1 Feb 2007

Benveniste Helene, Ma Yu, Dhawan Jasbeer, Gifford Andrew, Smith S David, Feinstein Igor, Du Congwu, Grant Samuel C, Hof Patrick R

Abstract excerpt

The wide variety of transgenic mouse models of Alzheimer's disease (AD) reflects the search for specific genes that influence AD pathology and the drive to create a clinically relevant animal model. An ideal AD mouse model must display hallmark AD pathology such as amyloid plaques, neurofibrillary tangles, reactive gliosis, dystrophic neurites, neuron and synapse loss, and brain atrophy and in parallel...

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PMID: 17413006
DOI: 10.1196/annals.1379.006

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