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Article

DTI reveals whole-brain microstructural changes in the P301L mouse model of tauopathy

2020-10-28

Abstract excerpt

<h4>Introduction</h4> Increased expression of hyperphosphorylated tau and the formation of neurofibrillary tangles are associated with neuronal loss and white matter damage. Using high resolution ex vivo diffusion tensor imaging (DTI), we investigated microstructural changes in the white and grey matter in the P301L mouse model of human tauopathy at 8.5 months-of-age. For unbiased computational analysis, we impl...

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Literature Corpus work
3fbc2c01-4c12-5ab7-bb8f-17f1020cfbd4
DOI
10.1101/2020.10.28.358465
Open publication

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DTI reveals whole-brain microstructural changes in the P301L mouse model of tauopathyDOI 10.1101/2020.10.28.358465
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