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Article

EFL-3/E2F7 modulates Wnt signalling by repressing the Nemo-like kinase LIT-1 during asymmetric epidermal cell division in Caenorhabditis elegans.

Development (Cambridge, England) - 1 Mar 2025

Ferrando-Marco Mar, Barkoulas Michalis

Abstract excerpt

The E2F family of transcription factors is conserved in higher eukaryotes and plays pivotal roles in controlling gene expression during the cell cycle. Most canonical E2Fs associate with members of the Dimerisation Partner (DP) family to activate or repress target genes. However, atypical repressors, such as E2F7 and E2F8, lack DP interaction domains and their functions are less understood. We report here that...

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Source

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Identifiers

PMID: 40026193
DOI: 10.1242/dev.204546
PMCID: PMC11925398

Genes

E2F7
E2F8
NLK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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