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Article

Promotion of oogenesis and embryogenesis in theC. elegansgonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)

20 Jul 2006

Abstract excerpt

In Caenorhabditis elegans, EFL-1 (E2F), DPL-1 (DP) and LIN-35 (pRb) act coordinately in somatic tissues to inhibit ectopic cell division, probably by repressing the expression of target genes. EFL-1, DPL-1 and LIN-35 are also present in the germline, but do not always act together. Strong loss-of-function mutations in either efl-1 or dpl-1 cause defects in oogenesis that result in sterility, while lin-35 mutants...

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PMID: 16854972
DOI: 10.1242/dev.02490

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