Article
Otefin, a nuclear membrane protein, determines the fate of germline stem cells in Drosophila via interaction with Smad complexes.
Developmental cell - 1 Apr 2008
Jiang Xiaoyong, Xia Laixin, Chen Dongsheng, Yang Yingyue, Huang Haidong, Yang Lele, Zhao Qiudong, Shen Lijun, Wang Jun, Chen Dahua
Abstract excerpt
Nuclear envelope proteins play important roles in chromatin organization, gene regulation, and signal transduction; however, the physiological role of these proteins remains elusive. We found that otefin (ote), which encodes a nuclear lamin-binding protein [corrected], is essential for germline stem cell (GSC) maintenance. We show that Ote, as an intrinsic factor, is both necessary and sufficient to regulate GSC...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.