Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents.

doi:10.1085/jgp.202213312

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Article

Cold and warmth intensify pain-linked sodium channel gating effects and persistent currents.

The Journal of general physiology - 4 Sept 2023

Kriegeskorte Sophia, Bott Raya, Hampl Martin, Korngreen Alon, Hausmann Ralf, Lampert Angelika

Abstract excerpt

Voltage-gated sodium channels (Nav) are key players in excitable tissues with the capability to generate and propagate action potentials. Mutations in the genes encoding Navs can lead to severe inherited diseases, and some of these so-called channelopathies show temperature-sensitive phenotypes, for example, paramyotonia congenita, Brugada syndrome, febrile seizure syndromes, and inherited pain syndromes like...

Topics

Erythromelalgia
Pain
Mutation
Humans
Channelopathies
Rectum
NAV1.7 Voltage-Gated Sodium Channel

Source

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Identifiers

PMID: 37531097
DOI: 10.1085/jgp.202213312
PMCID: PMC10397059

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