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Article

A hot topic: temperature sensitive sodium channelopathies.

Channels (Austin, Tex.) - 1 Jan 2000

Egri Csilla, Ruben Peter C

Abstract excerpt

Perturbations to body temperature affect almost all cellular processes and, within certain limits, results in minimal effects on overall physiology. Genetic mutations to ion channels, or channelopathies, can shift the fine homeostatic balance resulting in a decreased threshold to temperature induced disturbances. This review summarizes the functional consequences of currently identified voltage-gated sodium (NaV)...

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PMID: 22643347
DOI: 10.4161/chan.19827

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