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Article

Cardiovascular Risk Predicts White Matter Hyperintensities, Brain Atrophy and Treatment Resistance in Major Depressive Disorder: Role of Genetic Liability.

Acta psychiatrica Scandinavica - 1 Jun 2025

Paolini Marco, Maccario Melania, Saredi Virginia, Verri Anna, Calesella Federico, Raffaelli Laura, Lorenzi Cristina, Spadini Sara, Zanardi Raffaella, Colombo Cristina, Poletti Sara, Benedetti Francesco

Abstract excerpt

INTRODUCTION: Depressive disorders are a leading cause of global disease burden, particularly with the challenge of treatment-resistant depression (TRD). Research points to a complex bidirectional relationship between cardiovascular (CV) risk factors and TRD, with CV risk negatively impacting brain structure and potentially influencing antidepressant resistance. Moreover, the association between depression and...

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PMID: 40014927
DOI: 10.1111/acps.13793
PMCID: PMC12045660

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TRD

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