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Article

Comparative polygenic predispositions of treatment-resistant depression in East Asian and European populations.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Mar 2026

Cheng Chi-Fung, Kao Wei-Yi, Lin Mei-Chen, Su Mei-Hsin, Wu Chi-Shin, Fan Chun-Chieh, Wang Shi-Heng

Abstract excerpt

Large-scale genetic studies of treatment-resistant depression (TRD) have been performed majority on European ancestry cohorts, potentially missing important population-specific biological insights. Understanding the genetic predisposition for TRD across populations could provide insights for etiologic heterogeneity. Conducting a cohort study of 106,796 unrelated participants using Taiwan Biobank (TWBB), we...

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Identifiers

PMID: 40973771
DOI: 10.1038/s41386-025-02242-9
PMCID: PMC12932758

Genes

TRD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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