Article

Neuroanatomical dimensions in major depression: external validation and links with cognition, adverse life events, self-harm, metabolomics and genetics

2025-03-26

Abstract excerpt

<title>Abstract</title> <p>Major depressive disorder (MDD) is a leading cause of disability worldwide, yet its diagnosis relies on clinical symptoms alone. Using machine learning applied to deeply phenotyped, medication-free participants with MDD, we identified two neuroanatomical dimensions. Dimension 2 (D2), compared to Dimension 1 (D1), was characterized by reductions in grey and white matter and was associate...

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Literature Corpus work: b3287085-27aa-59ba-ada0-b3996a537811
DOI: 10.21203/rs.3.rs-5975731/v1

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