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Article

Cerebral Small Vessel Disease and Association With Higher Incidence of Depressive Symptoms in a General Elderly Population: The AGES-Reykjavik Study.

The American journal of psychiatry - 1 Jun 2015

van Sloten Thomas T, Sigurdsson Sigurdur, van Buchem Mark A, Phillips Caroline L, Jonsson Palmi V, Ding Jie, Schram Miranda T, Harris Tamara B, Gudnason Vilmundur, Launer Lenore J

Abstract excerpt

OBJECTIVE: The vascular depression hypothesis postulates that cerebral small vessel disease (CSVD) leads to depressive symptoms by disruption of brain structures involved in mood regulation. However, longitudinal data on the association between CSVD and depressive symptoms are scarce. The authors investigated the association between CSVD and incident depressive symptoms. METHOD: Longitudinal data were taken from...

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Source

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Identifiers

PMID: 25734354
DOI: 10.1176/appi.ajp.2014.14050578
PMCID: PMC4451386

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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