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The genetic landscape of kynurenine predicts neurovascular pathology and disrupted white matter integrity in patients with mood disorders

2024-12-12

Abstract excerpt

Low-grade systemic inflammation is linked to cardiometabolic diseases and increased cardiovascular risk. Patients with mood disorders, such as Major Depressive Disorder (MDD) and Bipolar Disorder (BD), also show elevated cardiovascular risk and inflammatory markers, suggesting shared biological pathways between mood and cardiometabolic conditions. The kynurenine (KYN) pathway, activated by inflammatory cytokines a...

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Literature Corpus work
f0907c30-4581-5375-931e-89b1e4c1dcf2
DOI
10.1101/2024.12.11.24317786
Open publication

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The genetic landscape of kynurenine predicts neurovascular pathology and disrupted white matter integrity in patients with mood disordersDOI 10.1101/2024.12.11.24317786
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