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Article

Unraveling the causal relationships between depression and brain structural imaging phenotypes: A bidirectional Mendelian Randomization study.

Brain research - 1 Oct 2024

Wang Wenqin, Jia Wenhui, Wang Shaoying, Wang Ying, Zhang Zhihui, Lei Minghuan, Zhai Ying, Xu Jinglei, Sun Jinghan, Zhang Wanwan, Wang Yao, Jiang Yurong, Jiang Yifan, Liu Mengge, Sun Zuhao, Liu Feng

Abstract excerpt

BACKGROUND: Previous studies have revealed structural brain abnormalities in individuals with depression, but the causal relationship between depression and brain structure remains unclear. METHODS: A genetic correlation analysis was conducted using summary statistics from the largest genome-wide association studies for depression (N = 674,452) and 1,265 brain structural imaging-derived phenotypes (IDPs,...

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PMID: 38825161
DOI: 10.1016/j.brainres.2024.149049

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