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Article

Endothelial cell-related genetic variants identify LDL cholesterol-sensitive individuals who derive greater benefit from aggressive lipid lowering.

Nature medicine - 1 Mar 2025

Marston Nicholas A, Kamanu Frederick K, Melloni Giorgio E M, Schnitzler Gavin, Hakim Aaron, Ma Rosa X, Kang Helen, Chasman Daniel I, Giugliano Robert P, Ellinor Patrick T, Ridker Paul M, Engreitz Jesse M, Sabatine Marc S, Ruff Christian T, Gupta Rajat M

Abstract excerpt

The role of endothelial cell (EC) dysfunction in contributing to an individual's susceptibility to coronary atherosclerosis and how low-density lipoprotein cholesterol (LDL-C) concentrations might modify this relationship have not been previously studied. Here, from an examination of genome-wide significant single nucleotide polymorphisms associated with coronary artery disease (CAD), we identified variants with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40011692
DOI: 10.1038/s41591-025-03533-w
PMCID: PMC13014400

Genes

CAD
PCSK9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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