Article

Polygenic Hyperlipidemias and Coronary Artery Disease Risk

2019-08-15

Abstract excerpt

<h4>Background</h4> Hyperlipidemia is a highly heritable risk factor for coronary artery disease (CAD). Monogenic familial hypercholesterolemia associates with higher increase in CAD risk than expected from a single LDL-C measurement, likely due to lifelong cumulative exposure to high LDL-C. It remains unclear to what extent a high polygenic load of LDL-C or TG-increasing variants associates with increased CAD ri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7dda4323-2305-55ca-a5b4-49c123fd65d6
DOI: 10.1101/735167

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Polygenic Hyperlipidemias and Coronary Artery Disease RiskDOI 10.1101/735167Read

Polygenic Hyperlipidemias and Coronary Artery Disease Risk.Semantic proximity Read

Polygenic Risk Score Modifies Risk of Coronary Artery Disease Conferred by Low-Density Lipoprotein CholesterolSemantic proximity Read

Monogenic and Polygenic Models of Coronary Artery Disease.Semantic proximity Read

Development of an Integrated Monogenic and Polygenic Risk Assessment Tool for Coronary Artery Disease and Its Application in a Community-Based Health Care Biobank.Semantic proximity Read

Associations of Blood Lipid-Related Polygenic Scores, Lifestyle Factors and Their Combined Effects with Risk of Coronary Artery Disease in the UK Biobank Cohort.Semantic proximity Read

Association of Genetically Predicted Levels of Circulating Blood Lipids with Coronary Artery Disease IncidenceSemantic proximity Read

Polygenic Contribution to Low-Density Lipoprotein Cholesterol Levels and Cardiovascular Risk in Monogenic Familial Hypercholesterolemia.Semantic proximity Read

Polygenic Background Modifies Risk of Coronary Artery Disease Among Individuals With Heterozygous Familial HypercholesterolemiaSemantic proximity Read

Validation of genome-wide polygenic risk scores for coronary artery disease in French CanadiansSemantic proximity Read

Polygenic modulation of lipoprotein(a)-associated cardiovascular riskSemantic proximity Read

Validation of Genome-Wide Polygenic Risk Scores for Coronary Artery Disease in French CanadiansSemantic proximity Read

Genome-wide polygenic score to identify a monogenic risk-equivalent for coronary diseaseSemantic proximity Read