Defects in pyruvate kinase cause a conditional increase of thiamine synthesis in Salmonella typhimurium.

Abstract excerpt

As genomic sequence data become more prevalent, the challenges in microbial physiology shift from identifying biochemical pathways to understanding the interactions that occur between them to create a robust but responsive metabolism. One of the most powerful methods to identify such interactions is in vivo phenotypic analysis. We have utilized thiamine synthesis as a model to detect subtle metabolic interactions...

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