Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii.

The Journal of biological chemistry - 1 Jan 2016

Nitzsche Richard, Zagoriy Vyacheslav, Lucius Richard, Gupta Nishith

Abstract excerpt

Toxoplasma gondii is a widespread protozoan parasite infecting nearly all warm-blooded organisms. Asexual reproduction of the parasite within its host cells is achieved by consecutive lytic cycles, which necessitates biogenesis of significant energy and biomass. Here we show that glucose and glutamine are the two major physiologically important nutrients used for the synthesis of macromolecules (ATP, nucleic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetates
Share to Glycolysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Intracellular Space

Share to Life Cycle Stages

Share to Oxidative Phosphorylation

Share to Parasites

Share to Toxoplasma

Share to Toxoplasmosis

Source

Open in PubMed Open full text

Identifiers

PMID: 26518878
DOI: 10.1074/jbc.M114.624619
PMCID: PMC4697150

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Metabolic Cooperation of Glucose and Glutamine Is Essential for the Lytic Cycle of Obligate Intracellular Parasite Toxoplasma gondii.PMID 26518878Read ↗

Pyruvate Homeostasis as a Determinant of Parasite Growth and Metabolic Plasticity in Toxoplasma gondiiSemantic proximity Read ↗

A plant/fungal-type phosphoenolpyruvate carboxykinase located in the parasite mitochondrion ensures glucose-independent survival of Toxoplasma gondii.Semantic proximity Read ↗

Mitochondrial Metabolism of Glucose and Glutamine Is Required for Intracellular Growth of Toxoplasma gondiiSemantic proximity Read ↗

Extracellular glutamine is essential in cell division and flagellar function in bloodstream forms of <i>Trypanosoma brucei</i>Semantic proximity Read ↗

Host-derived glucose and its transporter in the obligate intracellular pathogen <i>Toxoplasma gondii</i> are dispensable by glutaminolysisSemantic proximity Read ↗

Metabolic interactions between Toxoplasma gondii and its hostSemantic proximity Read ↗

A Toxoplasma gondii Gluconeogenic Enzyme Contributes to Robust Central Carbon Metabolism and Is Essential for Replication and VirulenceSemantic proximity Read ↗

Metabolic Adaptability and Nutrient Scavenging in Toxoplasma gondii: Insights from Ingestion Pathway-Deficient MutantsSemantic proximity Read ↗

Dual metabolomic profiling uncovers <i>Toxoplasma</i> manipulation of the host metabolome and the discovery of a novel parasite metabolic capabilitySemantic proximity Read ↗

Orientia tsutsugamushi infection reduces host gluconeogenic but not glycolytic substratesSemantic proximity Read ↗

Dual metabolomic profiling uncovers Toxoplasma manipulation of the host metabolome and the discovery of a novel parasite metabolic capabilitySemantic proximity Read ↗

Metabolic adaptability and nutrient scavenging in Toxoplasma gondii: insights from ingestion pathway-deficient mutants.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.