Article
CcpN controls central carbon fluxes in Bacillus subtilis.
Journal of bacteriology - 1 Sept 2008
Tännler Simon, Fischer Eliane, Le Coq Dominique, Doan Thierry, Jamet Emmanuel, Sauer Uwe, Aymerich Stéphane
Abstract excerpt
The transcriptional regulator CcpN of Bacillus subtilis has been recently characterized as a repressor of two gluconeogenic genes, gapB and pckA, and of a small noncoding regulatory RNA, sr1, involved in arginine catabolism. Deletion of ccpN impairs growth on glucose and strongly alters the distribution of intracellular fluxes, rerouting the main glucose catabolism from glycolysis to the pentose phosphate (PP)...
Topics
- Bacillus subtilis
- Bacterial Proteins
- Carbon Isotopes
- DNA-Binding Proteins
- Gene Expression Profiling
- Gene Expression Regulation, Bacterial
- Glucose
- Glyceraldehyde-3-Phosphate Dehydrogenase (NADP+)(Phosphorylating)
- Pentose Phosphate Pathway
- Phenotype