Back to search

Article

Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistance

2024-07-15

Abstract excerpt

<title>Abstract</title> <p>Colorectal Cancer (CRC) is a devastating disease, ranking second in cancer-related deaths. Immune checkpoint inhibitors (ICIs) have reshaped the prognosis of many cancers, including Microstatellite Instable (MSI) CRC. However, a significant proportion of MSI patients do not benefit from immunotherapy, prompting the selection of patients based on factors beyond microsatellite status. Mor...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
09d8822c-2598-5855-95d8-c29dd5e253d6
DOI
10.21203/rs.3.rs-4497628/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistanceDOI 10.21203/rs.3.rs-4497628/v1
Colorectal cancer patients-derived immunity-organoid platform unveils cancer-specific tissue markers associated with immunotherapy resistanceSemantic proximity
The next bastion to be conquered in immunotherapy: microsatellite stable colorectal cancerSemantic proximity
Unraveling Resistance to Immunotherapy in MSI-High Colorectal CancerSemantic proximity
Refining colorectal cancer classification and clinical stratification through a single-cell atlasSemantic proximity
Immuno-genomic classification of colorectal cancer organoids reveals cancer cells with intrinsic immunogenic properties associated with patient survivalSemantic proximity
Conventional therapy induces tumor immunoediting and modulates the immune contexture in colorectal cancerSemantic proximity
A Comprehensive Biomarker Analysis of Microsatellite Unstable/Mismatch Repair Deficient Colorectal Cancer Cohort Treated with ImmunotherapySemantic proximity
Identified and Validated the Characterization of the Colorectal Cancer Tumor Immune MicroenvironmentSemantic proximity
Beyond Microsatellite Instability: Evolving Strategies Integrating Immunotherapy for Microsatellite Stable Colorectal CancerSemantic proximity
Immunotherapy with immune checkpoint inhibitors in colorectal cancer: what is the future beyond deficient mismatch-repair tumours?Semantic proximity
Multi-omics analyses of single cell-derived colorectal cancer organoids reveal intratumor heterogeneity and immune response diversitySemantic proximity
Multiomic molecular characterization of the response to combination immunotherapy in MSS/pMMR metastatic colorectal cancerSemantic proximity
Select a neighboring publication to make it the new centre.