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Structural variant and nucleosome occupancy dynamics postchemotherapy in a HER2+ breast cancer organoid model

24 Feb 2025

Abstract excerpt

The most common chemotherapeutics induce DNA damage to eradicate cancer cells, yet defective DNA repair can propagate mutations, instigating therapy resistance and secondary malignancies. Structural variants (SVs), arising from copy-number-imbalanced and -balanced DNA rearrangements, are a major driver of tumor evolution, yet understudied posttherapy. Here, we adapted single-cell template-strand sequencing...

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PMID: 39993200
DOI: 10.1073/pnas.2415475122

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