Article

DNA and RNA from the same single nucleus reveals interactions between genomic and transcriptomic landscapes in human tumor samples

2023-10-06

Abstract excerpt

To deepen our understanding of cancer heterogeneity and uncover the dynamic interactions of tumor and host cells, we introduce hybrid BAG-seq: a high-throughput, multi-omic method that simultaneously captures DNA and RNA from tens of thousands of individual single nuclei. This method provides dual molecular layer information: DNA to distinguish tumor from stroma, identify tumor subclones, and detect mutant stromal...

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Literature Corpus work: 0dbc1374-01ef-5e07-85d1-de9353d17353
DOI: 10.1101/2023.10.04.560973

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