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SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA Suppression

24 Feb 2025

Abstract excerpt

Triple-negative breast cancer (TNBC) is the most challenging subtype of the disease due to its aggressive nature and lack of targeted therapy options. To identify regulators of TNBC, we conducted a genome-wide CRISPR knockout screen in both three-dimensional (3D) tumor spheroid and two-dimensional cell culture models. The 3D spheroid model displayed unique potential in identifying putative tumor suppressors...

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PMID: 39992701
DOI: 10.1158/0008-5472.can-24-2801

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