Article
Detection of phenotype-specific therapeutic vulnerabilities in breast cells using a CRISPR loss-of-function screen.
Molecular oncology - 1 Aug 2021
Barkovskaya Anna, Goodwin Craig M, Seip Kotryna, Hilmarsdottir Bylgja, Pettersen Solveig, Stalnecker Clint, Engebraaten Olav, Briem Eirikur, Der Channing J, Moestue Siver A, Gudjonsson Thorarinn, Maelandsmo Gunhild M, Prasmickaite Lina
Abstract excerpt
Cellular phenotype plasticity between the epithelial and mesenchymal states has been linked to metastasis and heterogeneous responses to cancer therapy, and remains a challenge for the treatment of triple-negative breast cancer (TNBC). Here, we used isogenic human breast epithelial cell lines, D492 and D492M, representing the epithelial and mesenchymal phenotypes, respectively. We employed a CRISPR-Cas9...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.