Article

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissue

2021-03-22

Abstract excerpt

SWI/SNF and related chromatin remodeling complexes act as tissue-specific tumor suppressors and are frequently inactivated in different cancers. Although many regulatory activities of SWI/SNF have been identified using 2D cell culture, the effects of SWI/SNF alterations in more complex 3D tissues have remained poorly understood. Here we employed 3D cell culture conditions that yield transcriptomic states mirroring...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b5135559-829f-5e1c-a20c-65b1eb065b60
DOI: 10.1101/2021.03.21.436346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

SMARCA4 regulates spatially restricted metabolic plasticity in 3D multicellular tissueDOI 10.1101/2021.03.21.436346Read

SMARCA4: Current status and future perspectives in non-small-cell lung cancerSemantic proximity Read

SMARCA4 supports the oncogenic landscape of <i>KRAS</i> -driven lung tumorsSemantic proximity Read

Functional characterization of SMARCA4 variants identified by targeted exome-sequencing of 131,668 cancer patients.Semantic proximity Read

Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer.Semantic proximity Read

SMARCA4 Inhibits Breast Cancer Progression and Metastasis through RHOA SuppressionSemantic proximity Read

The role of SMARCA4 in lung cancerSemantic proximity Read

Smarcd3 is an epigenetic modulator of the metabolic landscape in pancreatic ductal adenocarcinomaSemantic proximity Read

SMARCA4 mutations and expression in lung adenocarcinoma: prognostic significance and impact on the immunotherapy response.Semantic proximity Read

Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer.Semantic proximity Read

The SWI/SNF complex regulates the expression of miR-222, a tumor suppressor microRNA in lung adenocarcinomaSemantic proximity Read

Mutational landscape of SWI/SNF complex genes reveal correlation to predictive biomarkers for immunotherapy sensitivity in lung adenocarcinoma patients.Semantic proximity Read

BAFfling pathologies: Alterations of BAF complexes in cancer.Semantic proximity Read