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Tumor cell migration screen identifies SRPK1 as breast cancer metastasis determinant

15 Mar 2015

Abstract excerpt

Tumor cell migration is a key process for cancer cell dissemination and metastasis that is controlled by signal-mediated cytoskeletal and cell matrix adhesion remodeling. Using a phagokinetic track assay with migratory H1299 cells, we performed an siRNA screen of almost 1,500 genes encoding kinases/phosphatases and adhesome- and migration-related proteins to identify genes that affect tumor cell migration speed...

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PMID: 25774502
DOI: 10.1172/jci74440

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