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Article

Clinicopathologic and Genomic Characterization of SMARCA4-Deficient Carcinoma of the Gallbladder.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2025

Jia Qiqi, Chen Yishan, Pan Yuyao, Gao Shan, Wei Xiaoyun, Fan Yangyang, Li Pengjun, Yang Zhe, Pu Jun, Nan Pengfei, Chang Hongyun, Zheng Jianyun, Zhang Guanjun, Liu Xi

Abstract excerpt

As a key subunit of the SWItch/sucrose nonfermentable chromatin-remodeling complex, SMARCA4 plays a critical role as a tumor suppressor in various tumors. However, the clinicopathological and molecular features of SMARCA4-deficient carcinoma of the gallbladder (SMARCA4-dGBC) have not been well explored. In this study, a retrospective cohort of 926 nonsquamous cell gallbladder carcinomas (GBCs) was analyzed on...

Read the complete abstract on PubMed

Topics

Humans
Transcription Factors
Female
Male
DNA Helicases
Middle Aged

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Aged

Gallbladder Neoplasms

Nuclear Proteins

Retrospective Studies

Biomarkers, Tumor

Adult

Aged, 80 and over

Carcinoma

Mutation

Immunohistochemistry

Source

Identifiers

PMID: 40789532
DOI: 10.1016/j.modpat.2025.100868

Genes

SMARCA4
TP53
ATR
CDK4

Provenance

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