Article
Whole-exome sequencing of over 4100 men of African ancestry and prostate cancer risk.
Human molecular genetics - 15 Jan 2016
Rand Kristin A, Rohland Nadin, Tandon Arti, Stram Alex, Sheng Xin, Do Ron, Pasaniuc Bogdan, Allen Alex, Quinque Dominique, Mallick Swapan, Le Marchand Loic, Kaggwa Sam, Lubwama Alex, Stram Daniel O, Watya Stephen, Henderson Brian E, Conti David V, Reich David, Haiman Christopher A
Abstract excerpt
Prostate cancer is the most common non-skin cancer in males, with a ∼1.5-2-fold higher incidence in African American men when compared with whites. Epidemiologic evidence supports a large heritable contribution to prostate cancer, with over 100 susceptibility loci identified to date that can explain ∼33% of the familial risk. To explore the contribution of both rare and common variation in coding regions to...
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