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Article

Prostate Cancer Germline Variations and Implications for Screening and Treatment.

Cold Spring Harbor perspectives in medicine - 4 Sept 2018

Dias Alexander, Kote-Jarai Zsofia, Mikropoulos Christos, Eeles Ros

Abstract excerpt

Prostate cancer (PCa) is a highly heritable disease, and rapid evolution of sequencing technologies has enabled marked progression of our understanding of its genetic inheritance. A complex polygenic model that involves common low-penetrance susceptibility alleles causing individually small but cumulatively significant risk and rarer genetic variants causing greater risk represent the current most accepted model....

Topics

BRCA2 Protein
Cell Cycle Proteins
Checkpoint Kinase 2
Colorectal Neoplasms, Hereditary Nonpolyposis
DNA Repair
Early Detection of Cancer
Genetic Predisposition to Disease
Genome-Wide Association Study
Germ-Line Mutation
Homeodomain Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Molecular Targeted Therapy

Nuclear Proteins

Polymorphism, Single Nucleotide

Prostate-Specific Antigen

Prostatic Neoplasms

Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 29101112
DOI: 10.1101/cshperspect.a030379
PMCID: PMC6120689

Genes

BRCA1
BRCA2
CHEK2
HOXB13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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