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Article

Prostate Cancer Germline Variations and Implications for Screening and Treatment.

Cold Spring Harbor perspectives in medicine - 4 Sept 2018

Dias Alexander, Kote-Jarai Zsofia, Mikropoulos Christos, Eeles Ros

Abstract excerpt

Prostate cancer (PCa) is a highly heritable disease, and rapid evolution of sequencing technologies has enabled marked progression of our understanding of its genetic inheritance. A complex polygenic model that involves common low-penetrance susceptibility alleles causing individually small but cumulatively significant risk and rarer genetic variants causing greater risk represent the current most accepted model....

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Source

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Identifiers

PMID: 29101112
DOI: 10.1101/cshperspect.a030379
PMCID: PMC6120689

Genes

BRCA1
BRCA2
CHEK2
HOXB13

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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