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Article

Systematic evaluation of underlying defects in DNA repair as an approach to case-only assessment of familial prostate cancer.

Oncotarget - 24 Nov 2015

Nicolas Emmanuelle, Arora Sanjeevani, Zhou Yan, Serebriiskii Ilya G, Andrake Mark D, Handorf Elizabeth D, Bodian Dale L, Vockley Joseph G, Dunbrack Roland L, Ross Eric A, Egleston Brian L, Hall Michael J, Golemis Erica A, Giri Veda N, Daly Mary B

Abstract excerpt

Risk assessment for prostate cancer is challenging due to its genetic heterogeneity. In this study, our goal was to develop an operational framework to select and evaluate gene variants that may contribute to familial prostate cancer risk. Drawing on orthogonal sources, we developed a candidate list of genes relevant to prostate cancer, then analyzed germline exomes from 12 case-only prostate cancer patients from...

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Identifiers

PMID: 26485759
DOI: 10.18632/oncotarget.5554
PMCID: PMC4741850

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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