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Germline genetic variants in men with prostate cancer and one or more additional cancers.

Cancer - 15 Oct 2017

Pilié Patrick G, Johnson Anna M, Hanson Kristen L, Dayno Megan E, Kapron Ashley L, Stoffel Elena M, Cooney Kathleen A

Abstract excerpt

BACKGROUND: Prostate cancer has a significant heritable component, and rare deleterious germline variants in certain genes can increase the risk of the disease. The aim of the current study was to describe the prevalence of pathogenic germline variants in cancer-predisposing genes in men with prostate cancer and at least 1 additional primary cancer. METHODS: Using a multigene panel, the authors sequenced germline...

Topics

Adult
Age of Onset
Aged
Aged, 80 and over
Ataxia Telangiectasia Mutated Proteins
BRCA2 Protein
Checkpoint Kinase 2
DNA Mutational Analysis
DNA-Binding Proteins
Fanconi Anemia Complementation Group N Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Fanconi Anemia Complementation Group Proteins

Genetic Predisposition to Disease

Germ-Line Mutation

Homeodomain Proteins

Humans

Male

Middle Aged

MutL Protein Homolog 1

Source

Open in PubMed Open full text

Identifiers

PMID: 28657667
DOI: 10.1002/cncr.30817
PMCID: PMC6108085

Genes

BRCA2
ATM
BRCA1
BRIP1
CHEK2
FGFR3
HOXB13
MLH1
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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