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Article

Polygenic Risk Score Modifies Prostate Cancer Risk of Pathogenic Variants in Men of African Ancestry.

Cancer research communications - 14 Dec 2023

Hughley Raymond W, Matejcic Marco, Song Ziwei, Sheng Xin, Wan Peggy, Xia Lucy, Hart Steven N, Hu Chunling, Yadav Siddhartha, Lubmawa Alexander, Kiddu Vicky, Asiimwe Frank, Amanya Colline, Mutema George, Job Kuteesa, Ssebakumba Mbaaga K, Ingles Sue A, Hamilton Ann S, Couch Fergus J, Watya Stephen, Conti David V, Darst Burcu F, Haiman Christopher A

Abstract excerpt

Prostate cancer risk is influenced by rare and common germline variants. We examined the aggregate association of rare germline pathogenic/likely pathogenic/deleterious (P/LP/D) variants in ATM, BRCA2, PALB2, and NBN with a polygenic risk score (PRS) on prostate cancer risk among 1,796 prostate cancer cases (222 metastatic) and 1,424 controls of African ancestry. Relative to P/LP/D non-carriers at average genetic...

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Identifiers

PMID: 38014910
DOI: 10.1158/2767-9764.CRC-23-0022
PMCID: PMC10720390

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