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Article

Rare Variation in TET2 Is Associated with Clinically Relevant Prostate Carcinoma in African Americans.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2016

Koboldt Daniel C, Kanchi Krishna L, Gui Bin, Larson David E, Fulton Robert S, Isaacs William B, Kraja Aldi, Borecki Ingrid B, Jia Li, Wilson Richard K, Mardis Elaine R, Kibel Adam S

Abstract excerpt

BACKGROUND: Common variants have been associated with prostate cancer risk. Unfortunately, few are reproducibly linked to aggressive disease, the phenotype of greatest clinical relevance. One possible explanation is that rare genetic variants underlie a significant proportion of the risk for aggressive disease. METHOD: To identify such variants, we performed a two-stage approach using whole-exome sequencing...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27486019
DOI: 10.1158/1055-9965.EPI-16-0373
PMCID: PMC5093030

Genes

TET2
MSH6
BRCA1
BRCA2
IMPACT
PARP2

Provenance

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