Article
Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity
15 Feb 2025
Abstract excerpt
In the study of brain tumors, patient-derived three-dimensional sphere cultures provide an important tool for studying emerging treatments. The growth of such spheroids depends on the combined effects of proliferation and migration of cells, but it is challenging to make accurate distinctions between increase in cell number versus the radial movement of cells. To address this, we formulate a novel model in the...
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