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Article

Estimating intratumoral heterogeneity from spatiotemporal data.

Journal of mathematical biology - 1 Dec 2018

Rutter E M, Banks H T, Flores K B

Abstract excerpt

Glioblastoma multiforme (GBM) is a malignant brain cancer with a tendency to both migrate and proliferate. We propose modeling GBM with heterogeneity in cell phenotypes using a random differential equation version of the reaction-diffusion equation, where the parameters describing diffusion (D) and proliferation ([Formula: see text]) are random variables. We investigate the ability to perform the inverse problem...

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Identifiers

PMID: 29737395
DOI: 10.1007/s00285-018-1238-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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