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Article

An Integrated Computational/Experimental Model of Tumor Invasion

1 Feb 2006

Abstract excerpt

The intracellular and extracellular dynamics that govern tumor growth and invasiveness in vivo remain poorly understood. Cell genotype and phenotype, and nutrient, oxygen, and growth factor concentrations are key variables. In previous work, using a reaction-diffusion mathematical model based on variables that directly describe tumor cell cycle and biology, we formulated the hypothesis that tumor morphology is...

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PMID: 16452218
DOI: 10.1158/0008-5472.can-05-3166

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