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Article

Emergent Properties of Tumor Microenvironment in a Real-Life Model of Multicell Tumor Spheroids

30 Nov 2010

Abstract excerpt

Multicellular tumor spheroids are an important in vitro model of the pre-vascular phase of solid tumors, for sizes well below the diagnostic limit: therefore a biophysical model of spheroids has the ability to shed light on the internal workings and organization of tumors at a critical phase of their development. To this end, we have developed a computer program that integrates the behavior of individual cells...

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PMID: 21152429
DOI: 10.1371/journal.pone.0013942

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