Article
From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response.
PLoS computational biology - 1 Feb 2020
Gallaher Jill A, Massey Susan C, Hawkins-Daarud Andrea, Noticewala Sonal S, Rockne Russell C, Johnston Sandra K, Gonzalez-Cuyar Luis, Juliano Joseph, Gil Orlando, Swanson Kristin R, Canoll Peter, Anderson Alexander R A
Abstract excerpt
Glioblastomas are aggressive primary brain tumors known for their inter- and intratumor heterogeneity. This disease is uniformly fatal, with intratumor heterogeneity the major reason for treatment failure and recurrence. Just like the nature vs nurture debate, heterogeneity can arise from intrinsic or environmental influences. Whilst it is impossible to clinically separate observed behavior of cells from their...
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