Article
Comparative analysis of the Mexico City Prospective Study and the UK Biobank identifies ancestry-specific effects on clonal hematopoiesis.
Nature genetics - 1 Mar 2025
Wen Sean, Kuri-Morales Pablo, Hu Fengyuan, Nag Abhishek, Tachmazidou Ioanna, Deevi Sri V V, Taiy Haeyam, Smith Katherine R, Loesch Douglas P, Burren Oliver S, Dhindsa Ryan S, Wasilewski Sebastian, Alegre-Díaz Jesus, Berumen Jaime, Emberson Jonathan, Torres Jason M, Collins Rory, Carss Keren, Wang Quanli, Petrovski Slavé, Tapia-Conyer Roberto, Fabre Margarete A, Harper Andrew R, Vassiliou George S, Mitchell Jonathan
Abstract excerpt
The impact of genetic ancestry on the development of clonal hematopoiesis (CH) remains largely unexplored. Here, we compared CH in 136,401 participants from the Mexico City Prospective Study (MCPS) to 416,118 individuals from the UK Biobank (UKB) and observed CH to be significantly less common in MCPS compared to UKB (adjusted odds ratio = 0.59, 95% confidence interval (CI) = [0.57, 0.61], P = 7.31 × 10-185)....
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