Article
Persistence of pre-leukemic clones during first remission and risk of relapse in acute myeloid leukemia.
Leukemia - 1 Jul 2018
Rothenberg-Thurley Maja, Amler Susanne, Goerlich Dennis, Köhnke Thomas, Konstandin Nikola P, Schneider Stephanie, Sauerland Maria C, Herold Tobias, Hubmann Max, Ksienzyk Bianka, Zellmeier Evelyn, Bohlander Stefan K, Subklewe Marion, Faldum Andreas, Hiddemann Wolfgang, Braess Jan, Spiekermann Karsten, Metzeler Klaus H
Abstract excerpt
Some patients with acute myeloid leukemia (AML) who are in complete remission after induction chemotherapy harbor persisting pre-leukemic clones, carrying a subset of leukemia-associated somatic mutations. There is conflicting evidence on the prognostic relevance of these clones for AML relapse. Here, we characterized paired pre-treatment and remission samples from 126 AML patients for mutations in 68...
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