Article
Clonal dynamics and clinical implications of postremission clonal hematopoiesis in acute myeloid leukemia.
Blood - 4 Nov 2021
Tanaka Tomoyuki, Morita Kiyomi, Loghavi Sanam, Wang Feng, Furudate Ken, Sasaki Yuya, Little Latasha, Gumbs Curtis, Matthews Jairo, Daver Naval, Pemmaraju Naveen, DiNardo Courtney D, Sasaki Koji, Yilmaz Musa, Kadia Tapan M, Ravandi Farhad, Konopleva Marina Y, Kantarjian Hagop M, Champlin Richard E, Al-Atrash Gheath, Garcia-Manero Guillermo, Wang Sa A, Futreal P Andrew, Takahashi Koichi
Abstract excerpt
Although clonal hematopoiesis (CH) can precede the development of acute myeloid leukemia (AML), it can also persist after achieving remission. Long-term clonal dynamics and clinical implications of persistent CH are not well understood. Here, we studied the prevalence, dynamics, and clinical implications of postremission CH in 164 AML patients who attained complete remission after induction chemotherapies....
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