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Slow-Cycling Cancer Stem Cells Regulate Progression and Chemoresistance in Colon Cancer

19 Aug 2020

Abstract excerpt

Abstract Cancer chemoresistance is often attributed to the presence of cancer stem cell (CSC)-like cells, but whether they are homogeneously chemoresistant remains unclear. We previously showed that in colon tumors, a subpopulation of LGR5+ CSC-like cells driven by TCF1 (TCF7), a Wnt-responsive transcription factor, were responsible for tumorigenicity. Here we demonstrate that the tumorigenic subpopulation of...

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PMID: 32816913
DOI: 10.1158/0008-5472.can-20-0378

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